Metastasis is a multifactorial condition that complicates cancer treatment options and widens the target of treatment. Matrix mettalopriteinases (MMPs) of the extracellular matrix (ECM) are involved in metastasis, thus they present as potential targets in halting cancer metastasis. The study was undertaken to investigate the influence of naringenin, a naturally occurring flavonoid on the metastasis of human prostate cancer cells (PC-3 and DU145). Naringenin was observed to be effective in reducing the viability and migratory percentage of PC-3 and DU145 cells. Naringenin significantly reduced the expression and activities of the chief MMPs (MMP-2 and MMP-9) as assessed by western blotting, real-time PCR and gelatin zymography analysis. The influence of naringenin on extracellular signal-regulated kinase (ERK) -ERK1/2 was analysed by western blotting. The results indicated that naringenin was able to effectively inhibit ERK1/2. Naringenin exposure also significantly suppressed the levels of reactive oxygen species (ROS). Naringenin thus stands as an effective chemotherapeutic agent for prostate cancer treatment that could be further explored.
It’s a big distinction, one that will be on my mind during National Breast Cancer Awareness Month. (Trust me, this year I’m aware.) I’ve even found myself dragged into little debates about it.
An essay or paper on The Cancer Awareness
After decades of struggling with various cancers, doctors are now becoming more aware of the causes of these diseases, how they can be treated, and what can be done to prevent them. According to Dr. Mustafa Maatouk, a surgeon who is specialized in treating breast cancer and who operates frequently at the American University of Beirut, most breast cancer cases can be detected in two ways. In the past, women who underwent mastectomy suffered seriously because of the physical distortion of their bodies after the surgery. Today, however, plastic surgery has breast Cancer Essays Free developed in such a way that it has become part of the treatment. Both the breast and the glands that produce wax in ears belong to the same family of glands. Researchers found that individuals with ear glands that produce wet wax have a double risk with respect to breast cancer in contrast to those whose ear glands produce dry wax.